First, special bone cells called osteoclasts break down bone. Then, other bone cells called osteoblasts create new bone. Osteoclasts and osteoblasts can coordinate well for most of your life. Eventually, this coordination can break down, and the osteoclasts begin to remove more bone than the osteoblasts can create.
How does osteoporosis affect bone cells?
Osteocytes, which are terminally differentiated osteoblasts embedded in mineralized bone, direct the timing and location of bone remodeling. In osteoporosis, the coupling mechanism between osteoclasts and osteoblasts is thought to be unable to keep up with the constant microtrauma to trabecular bone.
Which bone cell is more active in osteoporosis?
Excessive bone breakdown by osteoclasts is an important cause of bone fragility not only in osteoporosis, but also in other bone diseases such as hyperparathyroidism, Paget’s disease, and fibrous dysplasia (see Chapter 3).
What type of change in bone cell activity could cause osteoporosis?
In adults, the daily removal of small amounts of bone mineral, a process called resorption, is balanced by an equal deposition of new mineral in order to maintain bone strength. When this balance tips toward excessive resorption, bones weaken and over time can become brittle and prone to fracture (osteoporosis).
How does osteoporosis affect bone remodeling?
Osteoporosis is a common disorder of bone remodeling characterized by low bone mass and structural deterioration of bone; it causes bone fragility and an increased vulnerability to fractures (28).
What organs are affected by osteoporosis?
Osteoporotic bone breaks are most likely to occur in the hip, spine or wrist, but other bones can break too. In addition to causing permanent pain, osteoporosis causes some patients to lose height. When osteoporosis affects vertebrae, or the bones of the spine, it often leads to a stooped or hunched posture.
What is the best doctor to treat osteoporosis?
A variety of medical specialists treat people with osteoporosis, including internists, gynecologists, family doctors, endocrinologists, rheumatologists, physiatrists, orthopaedists, and geriatricians. There are a number of ways to find a doctor who treats osteoporosis patients.
Which hormone is responsible for osteoporosis?
Parathyroid hormone (PTH) is an important contributor to the bone remodeling process. High levels of PTH can activate osteoclasts and cause excessive bone breakdown. Calcium in your blood triggers the release of PTH.
How long do bone cells live?
Osteocytes, which comprise 90–95% of the total bone cells, are the most abundant and long-lived cells, with a lifespan of up to 25 years .
What are the 4 stages of bone remodeling?
ACTIVATION, RESORPTION, REVERSAL, FORMATION, and QUIESCENCE. The total process takes about 4 to 8 months, and occurs continually throughout our lives.
How does estrogen affect osteoporosis?
Estrogen, a hormone in women that protects bones, decreases sharply when women reach menopause, which can cause bone loss. This is why the chance of developing osteoporosis increases as women reach menopause.
How do you stop bone remodeling?
Bisphosphonates are the pharmaceutical treatment of choice in most osteoporosis cases, as bisphosphonates suppress the resorptive phase of bone remodeling by inhibiting osteoclasts.
What does endocrinology have to do with osteoporosis?
Endocrinologists specialize in treating and preventing bone loss and preventing fractures. In addition, endocrinologists treat disorders that may affect bones, such as hyperparathyroidism, low and high levels of calcium. Become familiar with osteoporosis risk factors.
What happens at the cellular level to cause osteoporosis?
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes bones to become weak and fragile, thus increasing the risk of fractures.