In adults, the daily removal of small amounts of bone mineral, a process called resorption, is balanced by an equal deposition of new mineral in order to maintain bone strength. When this balance tips toward excessive resorption, bones weaken and over time can become brittle and prone to fracture (osteoporosis).
What is the meaning of bone resorption?
Resorption is the breakdown and assimilation of old bone in the cycle of bone growth. The process of resorption (remodeling) involves the removal of hard bone tissue by osteoclasts followed by the laying down of new bone cells by osteoblasts.
Why bone resorption is needed?
Your bones have two kinds of cells that do all the work to remodel your skeleton as needed. Osteoclasts break down old bone and deliver it into your bloodstream (resorption), and osteoblasts build your bone where it needs to be reinforced (ossification).
What is bone resorption called?
Bone Resorption: Osteoclast Action and Proteolytic Enzymes. Bone resorption involves both dissolution of bone mineral and degradation of organic bone matrix. Osteoclasts are highly specialized to perform both of these functions.
How do you reduce bone resorption?
Bisphosphonates, RANKL inhibitors, SERMs—selective oestrogen receptor modulators, hormone replacement therapy and calcitonin are some of the common treatments. Light weight bearing exercise tends to eliminate the negative effects of bone resorption.
Does bone resorption cause pain?
If bone resorption in the jaw occurs for a long period of time, patients may experience pain while chewing, eating, and talking due to an ever-shrinking jaw bone.
How does vitamin D cause bone resorption?
Previous studies have shown that high doses of vitamin D did result in increased resorption of bone unless calcium was also supplemented. The active form of vitamin D called calcitriol increases the production of osteoclasts which enhance bone resorption.
What age does bone resorption generally begin?
From about age 25 to age 50, bone density tends to stay stable with equal amounts of bone formation and bone breakdown. After age 50, bone breakdown (resorption) outpaces bone formation and bone loss often accelerates, particularly at the time of menopause.
Can you wear dentures if you have bone loss?
Some denture wearers may opt for a permanent denture, or dentures that are permanently fixed in the mouth, like dental implants. However, patients with a significant amount of bone loss may not be good candidates for permanent dentures because there isn’t enough healthy bone in which to anchor the implants.
What stimulates bone resorption?
Hormones play a role in determining when bones go through resorption or formation. These include parathyroid hormone (PTH) and calcitonin. When the level of calcium in the blood is low, the parathyroid activates to release PTH which stimulates osteoclasts to remove bone, thus releasing calcium into the bloodstream.
What happens if you have bone loss in your teeth?
Left untreated, jawbone loss can result in issues with your remaining teeth, collapse or distortion of facial features, and a range of other concerns. The most common treatment for jawbone atrophy is a dental bone graft. If you are concerned about potential bone loss in your jaw, speak to your dentist right away.
What is the most common drug used to treat osteoporosis?
For both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates. Examples include: Alendronate (Binosto, Fosamax) Ibandronate (Boniva)