The ability of PPIs to alter bone mass an/or cause osteoporosis is also unclear. In animal studies the PPI omeprazole reduced bone density [68,69]. In contrast, some human studies report no effect of PPIs to cause alterations in bone turnover and/or bone density as well as no effect at causing osteoporosis .
Does omeprazole cause bone thinning?
High doses or long-term use of medicines called proton pump inhibitors (PPIs) can raise the risk of bone loss. PPIs, such as esomeprazole, lansoprazole, and omeprazole, are used for GERD (acid reflux), peptic ulcer, or heartburn. However, getting enough calcium and vitamin D may be enough to lower the risk.
What are the side effects of long-term use of omeprazole?
Taking omeprazole for more than a year may increase your chances of certain side effects, including:
- bone fractures.
- gut infections.
- vitamin B12 deficiency – symptoms include feeling very tired, a sore and red tongue, mouth ulcers and pins and needles.
Does omeprazole interfere with calcium absorption?
In a study of elderly women, administration of omeprazole decreased the absorption of calcium, presumably because the drug decreased the stomach’s production of hydrochloric acid, which is necessary for calcium absorption. The form of calcium used in the study to test calcium absorption was calcium carbonate.
Why does PPI cause osteoporosis?
Increased gastrin production and hypochlorhydria are the two main mechanisms that affect bone remodeling, mineral absorption, and muscle strength, contributing to increased fracture risk among PPI users. As a conclusion, there is a potential relationship between PPIs and fracture risks.
What are the dangers of taking omeprazole?
Common side effects of omeprazole include:
- abdominal pain.
- gas (flatulence)
- upper respiratory infection.
Does omeprazole cause weight gain?
Weight gain: Long-term use of omeprazole increases the risk of weight gain in patients with GERD.
Is it safe to take omeprazole daily?
You should not take it for more than 14 days or repeat a 14-day course more often than every 4 months unless directed by a doctor. Do not crush, break, or chew the tablet. This decreases how well Prilosec OTC works in the body.
Does omeprazole shorten your life?
MONDAY, July 3, 2017 (HealthDay News) — Popular heartburn medications like Nexium, Prilosec or Prevacid may increase your risk of early death when taken for extended periods, a new study suggests.
Is it safe to take omeprazole for years?
Doctor’s response. Omeprazole controls acid production in the stomach only and does not affect the acid/alkaline balance of the body. The drug has been in use for some 10 years and appears to be safe for long term use.
Can I take omeprazole with vitamins?
Interactions between your drugs
No interactions were found between omeprazole and Vitamins. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Does omeprazole affect B12?
The studies reviewed in this article clearly show that omeprazole therapy will decrease the absorption of vitamin B12 by preventing its cleavage from dietary proteins.
Can I take omeprazole with vitamin D?
Interactions between your drugs
No interactions were found between omeprazole and Vitamin D3.
What are the two medications that may cause osteoporosis after long term use?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
Does omeprazole cause hip pain?
Stop using omeprazole and call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; new or unusual pain in your wrist, thigh, hip, or back; seizure (convulsions);
How do you treat osteoporosis naturally?
In addition to staying away from tobacco and heavy drinking, here are a few things you can do to preserve your bones.
- Engage in Weight-Bearing Exercise. Weight-bearing and muscle-strengthening exercises stimulate bone formation and slow age-related bone loss. …
- Eat Plants and Fermented Foods. …
- Get More Sleep.