The valvular lesions caused by rheumatoid arthritis have been known for a long time. The valves may be affected by unspecific inflammatory changes or, specifically, by rheumatoid granulomas identical with subcutaneous nodules that lead to the malfunctioning of the aortic or the mitral valve.
Does rheumatoid arthritis affect oxygen levels?
Low partial pressure of oxygen, a condition known as hypoxia, is a relevant feature in RA since it is involved in angiogenesis, inflammation, apoptosis, cartilage degradation, energy metabolism, and oxidative damage.
How does rheumatoid arthritis affect your heart?
Inflammatory substances called cytokines fuel joint destruction in RA and blood vessel damage in CVD. Inflammation causes plaque build-up in the arteries, which slowly narrows blood vessels and blocks blood flow, and is the main cause of heart attack and stroke.
Can rheumatoid arthritis cause mitral valve prolapse?
Mitral valve prolapse was demonstrated in 5 patients. Aortic valve disease was not significantly more common in the RA patients than in the controls.
Which valve is most commonly affected by rheumatic heart disease?
Facts About Valvular Heart Disease
Rheumatic heart disease most commonly affects the mitral valve (which has only two leaflets; Figure 2) or the aortic valve, but any valve can be affected, and more than one can be involved.
What happens when RA attacks the lungs?
The lung problems most often linked to rheumatoid arthritis include: Scarring within the lungs. Scarring related to long-term inflammation (interstitial lung disease) may cause shortness of breath, a chronic dry cough, fatigue, weakness and loss of appetite.
What is the main cause of rheumatoid arthritis?
Rheumatoid arthritis is an autoimmune condition, which means it’s caused by the immune system attacking healthy body tissue. However, it’s not yet known what triggers this. Your immune system normally makes antibodies that attack bacteria and viruses, helping to fight infection.
Can a leaky mitral valve cause a stroke?
Mitral valve regurgitation can cause complications such as: Atrial fibrillation, in which the atria of the heart don’t contract well. This leads to increased risk of stroke. Elevated blood pressure in the lungs (pulmonary artery hypertension)
Does rheumatoid arthritis cause mitral stenosis?
Regurgitation is the most common form of valve disease, although stenosis has been reported (21, 24-26). The mitral valve was selectively involved in our RA patients, and mitral valve disease was significantly more common in the RA group than in the control group.
How do you know if you have rheumatic heart disease?
Rheumatic Heart Disease Signs and Symptoms
Symptoms of rheumatic fever, which can lead to rheumatic heart disease, include: Swelling, redness and pain in the joints. An inflammation of the heart muscle and tissue, causing a rapid heart rate, fatigue, shortness of breath and exercise intolerance. Fever.
What is the most common and serious problem that develops in a person with rheumatic heart disease?
The most common form of rheumatic heart disease affects the heart valves. It may take several years after an episode of rheumatic fever for valve damage to develop or symptoms to appear.