Bisphosphonates slow bone resorption by reducing osteoclast function. Many studies have shown that this class of medication can improve bone density and reduce the risk of fracture in patients with a reduced bone density.
How do bisphosphonates work in osteoporosis?
Bisphosphonates work by slowing down the cells which break down bone (osteoclasts). Therefore they slow down bone loss, allowing the bone building cells (osteoblasts) to work more effectively. They can help to strengthen bone and help to prevent it getting any weaker.
Why bisphosphonate administration is helpful in osteoporosis?
Oral and IV bisphosphonates reduce calcium efflux from bone and commonly cause a small decrease in serum calcium and compensatory rise in serum parathyroid hormone (PTH) [Chesnut et al. 1995].
How do bisphosphonates increase bone density?
By slowing or stopping the bone-resorbing portion of the remodeling cycle, bisphosphonates allow new bone formation to catch up with bone resorption. Fosamax and other drugs such as Actonel, Boniva, and Reclast increase bone density and help prevent and treat osteoporosis and/or reduce the risk of fractures.
How does bisphosphonates work in the body?
Bisphosphonates are a group of drugs that work by slowing bone loss. They reduce the risk of hip and spine fractures. Bone renewal is a slow process, but in many people an increase in bone density can be measured over five years of treatment.
How long should you stay on bisphosphonates?
Answer From Ann Kearns, M.D., Ph. D. Bisphosphonates, the most common type of osteoporosis medications, are typically taken for at least 3 to 5 years. After that, your doctor will consider your risk factors in determining whether you should continue to take these or other osteoporosis medications.
Who should not take bisphosphonates?
Don’t take bisphosphonates if you:
- Are allergic to them.
- Have disorders of the food pipe (esophagus), including tears, holes, narrowing, or difficulty swallowing.
- Have severe kidney disease.
- Can’t sit in an upright position for at least 30 minutes.
- Have low levels of calcium in your bloodstream.
What happens when you stop taking bisphosphonates?
When treatment is stopped, if there is continued presence of bisphosphonate in bone and continued release (and possible re-attachment to bone), there might be some lingering antifracture effect after treatment is stopped.
Which bisphosphonate is best for osteoporosis?
Oral – We suggest alendronate or risedronate as the initial choice of oral bisphosphonate (table 1). We most commonly use alendronate, in part due to direct evidence showing residual fracture benefit in selected patients after completing a five-year course of therapy .
Is sitting bad for osteoporosis?
“If you have low bone density, however, and you put a lot of force or pressure into the front of the spine — such as in a sit-up or toe touch — it increases your risk of a compression fracture.” Once you have one compression fracture, it can trigger a “cascade of fractures” in the spine, says Kemmis.
What are the two medications that may cause osteoporosis after long term use?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
Can osteoporosis be reversed without medication?
Can osteoporosis be reversed without medications? Your doctor diagnoses osteoporosis based on bone density loss. You can have different degrees of the condition, and catching it early can help you prevent the condition from worsening. You cannot reverse bone loss on your own.
Is there an alternative to bisphosphonates?
In recent years, the drug denosumab (Prolia) has emerged as an alternative to bisphosphonates for the treatment of postmenopausal osteoporosis. Denosumab may be considered a first-line treatment for women with osteoporosis who are at high risk of fracture or in women who can’t take bisphosphonates.
What are the side effects of using bisphosphonates?
Side effects for all the bisphosphonates (alendronate, ibandronate, risedronate and zoledronic acid) may include bone, joint or muscle pain. Side effects of the oral tablets may include nausea, difficulty swallowing, heartburn, irritation of the esophagus (tube connecting the throat to the stomach) and gastric ulcer.