Bone remodeling occurs in two phases. First, special bone cells called osteoclasts break down bone. Then, other bone cells called osteoblasts create new bone. Osteoclasts and osteoblasts can coordinate well for most of your life.
What cells are responsible for osteoporosis?
Osteoclasts, derived from hematopoietic precursors, are responsible for bone resorption, whereas osteoblasts, from mesenchymal cells, are responsible for bone formation (see the images below). The 2 types of cells are dependent on each other for production and linked in the process of bone remodeling.
Which types of bone cells are the culprit for osteoporosis?
The main culprits in bone loss are osteoclasts, which are the cells that break bone down and work in tandem with osteoblasts, which are cells that are responsible for bone formation, to maintain bone volume. But when those osteoclasts over-perform their function, the results are losses in bone density and bone.
What causes osteoporosis at a cellular level?
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation.
How are osteoblasts and osteoclasts related to osteoporosis?
Bone homeostasis depends on the resorption of bone by osteoclasts and formation of bone by osteoblasts. Imbalance of this tightly coupled process can cause diseases such as osteoporosis. Thus, the mechanisms that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology.
Which hormone is responsible for osteoporosis?
Parathyroid hormone (PTH) is an important contributor to the bone remodeling process. High levels of PTH can activate osteoclasts and cause excessive bone breakdown. Calcium in your blood triggers the release of PTH.
What is the best doctor to treat osteoporosis?
A variety of medical specialists treat people with osteoporosis, including internists, gynecologists, family doctors, endocrinologists, rheumatologists, physiatrists, orthopaedists, and geriatricians. There are a number of ways to find a doctor who treats osteoporosis patients.
Which cycle is affected by osteoporosis?
As we age, however, our bone cells begin to deteriorate while new bone cells form – in a cycle called “remodeling”. In the case of osteoporosis, the remodeling process is hindered when bone tissue dissolves faster than new tissue can keep up.
What can be done to prevent osteoporosis?
Diet, vitamin D and weight-bearing exercise can help to prevent osteoporosis. If you have osteoporosis, medical treatment can prevent further bone loss and reduce your risk of bone fractures.
What are 3 common causes of osteoporosis?
There are three common causes of osteoporosis:
- Estrogen Deficiencies in Women. Women typically suffer estrogen deficiencies during perimenopause and menopause. …
- Calcium Deficiencies. Bones are constantly losing and replacing minerals. …
- Inactive Lifestyle.
What can an endocrinologist do for osteoporosis?
Endocrinologists specialize in treating and preventing bone loss and preventing fractures. In addition, endocrinologists treat disorders that may affect bones, such as hyperparathyroidism, low and high levels of calcium. Become familiar with osteoporosis risk factors.
How does estrogen affect osteoporosis?
Estrogen, a hormone in women that protects bones, decreases sharply when women reach menopause, which can cause bone loss. This is why the chance of developing osteoporosis increases as women reach menopause.
Does osteoporosis increased osteoclast activity?
Osteoporosis thus is not only the result of an increase of osteoclastic activity, but also it is caused by the physiologic decrease of the osteoblastic activity. The capacity a bone has to resist to a fracture is determined by its quality, which can be estimated through its mass.