First, special bone cells called osteoclasts break down bone. Then, other bone cells called osteoblasts create new bone. Osteoclasts and osteoblasts can coordinate well for most of your life. Eventually, this coordination can break down, and the osteoclasts begin to remove more bone than the osteoblasts can create.
Does osteoporosis affect osteoclasts?
Osteocytes, which are terminally differentiated osteoblasts embedded in mineralized bone, direct the timing and location of bone remodeling. In osteoporosis, the coupling mechanism between osteoclasts and osteoblasts is thought to be unable to keep up with the constant microtrauma to trabecular bone.
What is the role of osteoclasts in the pathogenesis of osteoporosis?
Osteoclasts and osteoblasts are both important for the pathogenesis and progression of osteoporosis. Osteoclasts induce bone resorption and osteoblasts are associated with bone formation. Normal bone quality involves a neutral balance between resorption and formation.
How do osteoclasts break down bones?
Osteoclasts dissolve bone mineral by massive acid secretion and secrete specialized proteinases that degrade the organic matrix, mainly type I collagen, in this acidic milieu.
What do osteoclasts do and why?
Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.
What is the most common drug used to treat osteoporosis?
For both men and women at increased risk of fracture, the most widely prescribed osteoporosis medications are bisphosphonates. Examples include: Alendronate (Binosto, Fosamax) Ibandronate (Boniva)
What is the cellular mechanism of osteoporosis?
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes bones to become weak and fragile, thus increasing the risk of fractures.
Do osteoclasts build bone?
OSTEOCLASTS are large cells that dissolve the bone. … Osteoblasts work in teams to build bone. They produce new bone called “osteoid” which is made of bone collagen and other protein. Then they control calcium and mineral deposition.
Do osteoclasts destroy bone?
Bone remodelling relies on the correct function of two principal cells of the bone tissue: the osteoclasts, multinucleated cells that destroy the bone matrix, and the osteoblasts, having osteogenic functions.
Why are osteoclasts actually important in bone growth?
Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/ monocyte lineage that circulate in the blood after their formation in the bone marrow.
Why are osteoclasts so important?
Osteoclasts are the only bone resorbing cells. They are essential in healthy bone development and bone remodeling. Dysfunction of osteoclasts results in deficiency of bone turnover and in osteopetrotic-like diseases.