An abnormal protein level in the CSF suggests a problem in the central nervous system. Increased protein level may be a sign of a tumor, bleeding, nerve inflammation, or injury. A blockage in the flow of spinal fluid can cause the rapid buildup of protein in the lower spinal area.
Is protein in CSF normal?
The normal range for a protein level is 15 to 45 milligrams per deciliter (mg/dL). Milligrams per deciliter is a measurement that looks at the concentration of something in an amount of fluid. Children have a lower protein level than adults.
Can elevated levels of protein in spinal fluid mean you might have MS?
Cerebral spinal fluid studies can confirm demyelinating disease of the nervous system. They show an increase in immunoglobulin concentrations in more than 90% of patients with MS. IgG index (a comparison between IgG levels in the CSF and in the serum) is elevated in many MS patients.
What proteins are present in CSF?
The spinal fluid normally contains very little protein since serum proteins are large molecules that do not cross the blood-brain barrier. Most of the protein that is normally present is albumin.
What can spinal fluid tell you?
A CSF analysis may include tests to diagnose: Infectious diseases of the brain and spinal cord, including meningitis and encephalitis. CSF tests for infections look at white blood cells, bacteria, and other substances in the cerebrospinal fluid.
What is normal CSF protein level?
The normal protein range varies from lab to lab, but is typically about 15 to 60 milligrams per deciliter (mg/dL) or 0.15 to 0.6 milligrams per milliliter (mg/mL). Normal value ranges may vary slightly among different laboratories.
Why does glucose decrease with meningitis?
The reason for the reduced glucose levels associated with bacterial meningitis was believed to be the need for glucose as fuel by infiltrating immune cells in response to infection. However, the possibility that the bacteria itself could manipulate glucose concentrations in the brain had not been explored before now.
Does a lumbar puncture confirm MS?
A lumbar puncture is a common test used to diagnose MS, and it’s a relatively simple test to perform. It’s generally the first step in determining whether you have MS if you’re showing symptoms. Your doctor will determine whether further tests are needed to confirm a diagnosis.
Does clear spinal fluid mean no MS?
The CSF is clear and colorless in all patients with MS, and most patients have normal cell counts and total protein levels. Even during an acute exacerbation, total CSF protein and cell counts remain normal, although sometimes a modest mononuclear pleocytosis can be identified.
What does high glucose in spinal fluid mean?
Abnormal results include higher and lower glucose levels. Abnormal results may be due to: Infection (bacterial or fungus) Inflammation of the central nervous system. Tumor.
What can cause increased CSF?
What causes increased ICP?
- Hydrocephalus, which is an abnormal buildup of cerebrospinal fluid. This is the fluid around your brain and spinal cord.
- Bleeding into the brain.
- Swelling in the brain.
- Blood pooling in some part of the brain.
- Brain or head injury.
- Brain tumor.
- Infections such as encephalitis or meningitis.
What is normal WBC count in CSF?
Understanding your test results
Normally, there are no RBCs in the cerebrospinal fluid, and there should be no more than five WBCs per cubic millimeter of CSF. If your fluid contains RBCs, this may indicate bleeding.
Why is CSF glucose normal in viral meningitis?
Cerebrospinal fluid (CSF) glucose levels may be decreased in any central nervous system infection, although levels are typically normal in viral meningitis, low in bacterial meningitis, and may be normal or low in fungal meningitis. CSF glucose levels are normally about 60% of blood glucose levels.