In osteoporosis, the coupling mechanism between osteoclasts and osteoblasts is thought to be unable to keep up with the constant microtrauma to trabecular bone.
What causes osteoporosis osteoclasts?
High levels of PTH can activate osteoclasts and cause excessive bone breakdown. Calcium in your blood triggers the release of PTH. Low calcium levels in the blood, or hypocalcemia, can cause high levels of PTH. It can also cause your own bone to release calcium to make sure you have enough calcium in your blood.
Does osteoporosis affect osteoclasts?
Bone homeostasis depends on the resorption of bone by osteoclasts and formation of bone by osteoblasts. Imbalance of this tightly coupled process can cause diseases such as osteoporosis. Thus, the mechanisms that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology.
What is the role of osteoclasts in the pathogenesis of osteoporosis?
Osteoclasts and osteoblasts are both important for the pathogenesis and progression of osteoporosis. Osteoclasts induce bone resorption and osteoblasts are associated with bone formation. Normal bone quality involves a neutral balance between resorption and formation.
What is the best doctor to treat osteoporosis?
A variety of medical specialists treat people with osteoporosis, including internists, gynecologists, family doctors, endocrinologists, rheumatologists, physiatrists, orthopaedists, and geriatricians. There are a number of ways to find a doctor who treats osteoporosis patients.
Do osteoclasts build bone?
OSTEOCLASTS are large cells that dissolve the bone. … Osteoblasts work in teams to build bone. They produce new bone called “osteoid” which is made of bone collagen and other protein. Then they control calcium and mineral deposition.
What does endocrinology have to do with osteoporosis?
Endocrinologists specialize in treating and preventing bone loss and preventing fractures. In addition, endocrinologists treat disorders that may affect bones, such as hyperparathyroidism, low and high levels of calcium. Become familiar with osteoporosis risk factors.
How is osteoporosis related to bone remodeling?
Osteoporosis is a common disorder of bone remodeling characterized by low bone mass and structural deterioration of bone; it causes bone fragility and an increased vulnerability to fractures (28).
What cell causes osteoporosis?
Excessive bone breakdown by osteoclasts is an important cause of bone fragility not only in osteoporosis, but also in other bone diseases such as hyperparathyroidism, Paget’s disease, and fibrous dysplasia (see Chapter 3).
What is the cellular mechanism of osteoporosis?
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes bones to become weak and fragile, thus increasing the risk of fractures.
How can you prevent and manage osteoporosis?
Prevention of osteoporosis
- have a healthy and varied diet with plenty of fresh fruit, vegetables and whole grains.
- eat calcium-rich foods.
- absorb enough vitamin D.
- avoid smoking.
- limit alcohol consumption.
- limit caffeine.
- do regular weight-bearing and strength-training activities.
Will osteoporosis shorten my life?
The residual life expectancy of a 50-year-old man beginning osteoporosis treatment was estimated to be 18.2 years and that of a 75-year-old man was 7.5 years. Estimates in women were 26.4 years and 13.5 years, respectively.
How should you sleep with osteoporosis?
What’s the best sleeping position for osteoporosis of the spine? Sleeping on your side or back are both viewed as suitable for those with brittle bones. You may want to avoid sleeping on your stomach because it can cause too much of an arch in the back, which is both unhealthy and uncomfortable.
What are the two medications that may cause osteoporosis after long term use?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.