Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the first cause in young people. Bone loss and increased rate of fractures occur early after the initiation of corticosteroid therapy, and are then related to dosage and treatment duration.
How do steroids cause osteoporosis?
Causes and Risk Factors
Corticosteroids tend to both reduce the body’s ability to absorb calcium and increase how fast bone is broken down. The more of these drugs you take and the longer you take them, the greater your risk of developing osteoporosis.
Is steroid-induced osteoporosis reversible?
The accompanying biochemical changes, particularly the marked increase in serum osteocalcin levels, confirm that enhanced bone formation occurred during the recovery phase. These findings suggest that steroid-induced osteoporosis can be reversed at least in young persons.
How can you prevent steroid-induced osteoporosis?
What can be done to prevent steroid-induced osteoporosis?
- Stopping smoking.
- Limiting alcohol intake.
- Taking more exercise (particularly weight-bearing exercise).
- Having an adequate calcium and vitamin D intake, and considering supplements if you are not getting enough calcium and/or vitamin D.
How is steroid-induced osteoporosis treated?
The first-line drugs for treatment of glucocorticoid-induced osteoporosis include bisphosphonates: alendronate and risedronate, while zoledronate or teriparatide should be considered as the second option. The effectiveness of other therapeutic agents has not been proven yet.
What are the worst side effects of prednisone?
What are the serious side effects of prednisone?
- Puffiness of the face (moon face)
- Growth of facial hair.
- Thinning and easy bruising of the skin.
- Impaired wound healing.
- Ulcers in the stomach and duodenum.
What should you not eat when taking prednisone?
Prednisone has a tendency to raise the level of glucose, or sugar, in the blood, which can cause increased body fat or diabetes in some people. It is important to avoid “simple” carbohydrates and concentrated sweets, such as cakes, pies, cookies, jams, honey, chips, breads, candy and other highly processed foods.
How long does it take for prednisone to cause osteoporosis?
How quickly can bone loss occur when taking a steroids? Bone loss occurs most rapidly in the first 6 months after starting oral steroids.
What does prednisone do to bones?
Prednisone is a corticosteroid, a type of medication that’s very effective in managing inflammation in rheumatoid arthritis and many other conditions. Unfortunately, corticosteroids also can dramatically weaken bones and lead to osteoporosis.
Is it OK to take vitamin D with predniSONE?
Does vitamin D interact with other medications? Yes. Steroid medications such as prednisone can interfere with vitamin D metabolism. If you take steroid drugs regularly, discuss vitamin D with your doctor.
Can you reverse the effects of osteoporosis?
Can osteoporosis be reversed without medications? Your doctor diagnoses osteoporosis based on bone density loss. You can have different degrees of the condition, and catching it early can help you prevent the condition from worsening. You cannot reverse bone loss on your own.
What are some side effects of prednisone?
Side effects of oral corticosteroids
- Fluid retention, causing swelling in your lower legs.
- High blood pressure.
- Problems with mood swings, memory, behavior, and other psychological effects, such as confusion or delirium.
- Upset stomach.
- Weight gain, with fat deposits in your abdomen, your face and the back of your neck.
What is considered long term for prednisone use?
Treatment extending longer than three months is considered long term and results in the majority of severe side effects.
What causes glucocorticoid induced osteoporosis?
The main causes of GC use are inflammatory rheumatic disorders (rheumatoid arthritis, polymyalgia rheumatic…) and lung disorders (asthma and chronic obstructive lung diseases). Apart from bone and ocular side effects, lipodystrophy and neuropsychiatric disorders are also common adverse events of long-term GC therapy.
How do you prevent glucocorticoid induced osteoporosis?
The strongest data available involve the use of bisphosphonates, including etidronate, alendronate, and risedronate, which have been shown to maintain or increase bone density and in some studies decrease fracture risk. Parathyroid hormone treatment also can reverse glucocorticoid-induced osteoporosis.