Best answer: Which diabetic medication causes osteoporosis?

One class of antidiabetic drugs, thiazolidinediones (TZDs), causes bone loss and further increases facture risk, placing TZDs in the category of drugs causing secondary osteoporosis.

What medications cause osteoporosis?

The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.

Can metformin cause osteoporosis?

Metformin has a certain effect on microangiopathy and anti-inflammation, which can induce osteoporosis, activate the activity of osteoclasts, and inhibit osteoblast activity, and has demonstrated extensive alteration in bone and mineral metabolism.

Does type 2 diabetes cause osteoporosis?

Did you know that diabetes can also affect your bone health? Individuals with Type 1 diabetes (the loss of insulin produced by the pancreas) or Type 2 diabetes (the body’s inability to use insulin and a slow loss of one’s ability to make insulin) have an increased risk of bone fractures and osteoporosis.

Does Actos cause bone loss?

Thiazolidinediones have been found to cause bone loss in some rodent models. In humans, their effects may occur because of increased bone marrow adiposity, decreased osteoblast activity, or reduced aromatase activity leading to altered estrogen production and increased bone resorption.

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Can osteoporosis cause eye problems?

Osteoporosis is associated with increased risk of developing dry eye syndrome, which can cause blurred vision and increase the risk of fall and fracture.

How do you treat osteoporosis without medication?

They include walking, hiking, jogging, climbing stairs, playing tennis, yoga and dancing. Resistance exercises – such as lifting weights – can also strengthen bones.” Kamhi lays it all out in an article she wrote for Natural Medical Journal.

What are the side effects to metformin?

Side Effects

Nausea, vomiting, stomach upset, diarrhea, weakness, or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away.

Does metformin cause bone pain?

Type 2 diabetes, metformin use and musculoskeletal (back, knee, hip and neck/shoulder) pain were self-reported. Participants reported musculoskeletal pain that had interfered with their usual activities in the last month (recent pain), and for more than 3 months (chronic pain).

Why do diabetics become thin and weak?

Diabetes and sudden weight loss

In people with diabetes, insufficient insulin prevents the body from getting glucose from the blood into the body’s cells to use as energy. When this occurs, the body starts burning fat and muscle for energy, causing a reduction in overall body weight.

Why is diabetes a risk factor for osteoporosis?

The diabetes–osteoporosis link

It is possible that people with type 1 diabetes achieve lower peak bone mass, the maximum strength and density that bones reach. People usually reach their peak bone mass in their 20s. Low peak bone mass can increase one’s risk of developing osteoporosis later in life.

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What are the two types of osteoporosis?

Two categories of osteoporosis have been identified: primary and secondary. Primary osteoporosis is the most common form of the disease and includes postmenopausal osteoporosis (type I), and senile osteoporosis (type II). Secondary osteoporosis is characterized as having a clearly definable etiologic mechanism.

How do glitazones cause osteoporosis?

The mechanism of TZD-induced bone loss includes unbalanced bone remodeling processes resulting from decreased bone formation and increased bone resorption.

Can pioglitazone cause heart failure?

Despite a significantly increased risk for serious heart failure with pioglitazone, a similar number of patients in both treatment groups had a fatal SAE of heart failure (considered the primary cause of death), with fatal heart failure events occurring in 25 (0.96%) in the pioglitazone group and 22 (0.84%) in the …

What are the side effects of pioglitazone?

More common

  • Blurred vision or other changes in vision.
  • flushed, dry skin.
  • fruit-like breath odor.
  • headache.
  • increased thirst.
  • increased urination.
  • muscle pain or soreness.
  • problems with your teeth.
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