Metformin has a certain effect on microangiopathy and anti-inflammation, which can induce osteoporosis, activate the activity of osteoclasts, and inhibit osteoblast activity, and has demonstrated extensive alteration in bone and mineral metabolism.
Which diabetic medication causes osteoporosis?
One class of antidiabetic drugs, thiazolidinediones (TZDs), causes bone loss and further increases facture risk, placing TZDs in the category of drugs causing secondary osteoporosis.
What medications can increase risk of osteoporosis?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
Can metformin cause osteopenia?
In general, diabetic patients have lower bone quality in comparison with non-diabetic individuals and it has been reported that DM can affect bone tissue (osteopenia and osteoporosis) due to hyperinsulinemia, reduced serum levels of IGF-1, presentation of advanced glycosylation of end-products (AGEs) especially in …
Why does diabetes cause osteoporosis?
Diabetes mellitus (DM) increases osteoclast function but decreases osteoblast function, thereby leading to accelerated bone loss, osteopenia and osteoporosis.
What are the side effects to metformin?
Nausea, vomiting, stomach upset, diarrhea, weakness, or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away.
Is metformin good for bones?
Metformin, a widely used antidiabetic drug, has been shown to improve bone quality and decrease the risk of fractures in patients with diabetes in addition to glycemic control and improving insulin sensitivity.
How do you treat osteoporosis without medication?
They include walking, hiking, jogging, climbing stairs, playing tennis, yoga and dancing. Resistance exercises – such as lifting weights – can also strengthen bones.” Kamhi lays it all out in an article she wrote for Natural Medical Journal.
Is fasting good for osteoporosis?
This has been found by the biochemical markers, indicating that fasting at certain hours of the day, especially during those hours of the day which are recommended as part of the Muslim tradition, is very effective in reducing the effects of osteoporosis.
How can I rebuild my bones?
10 Natural Ways to Build Healthy Bones
- Eat Lots of Vegetables. …
- Perform Strength Training and Weight-Bearing Exercises. …
- Consume Enough Protein. …
- Eat High-Calcium Foods Throughout the Day. …
- Get Plenty of Vitamin D and Vitamin K. …
- Avoid Very Low-Calorie Diets. …
- Consider Taking a Collagen Supplement. …
- Maintain a Stable, Healthy Weight.
Does metformin cause bone pain?
Type 2 diabetes, metformin use and musculoskeletal (back, knee, hip and neck/shoulder) pain were self-reported. Participants reported musculoskeletal pain that had interfered with their usual activities in the last month (recent pain), and for more than 3 months (chronic pain).
Does metformin help osteoarthritis?
Metformin attenuates osteoarthritis structural worsening and modulates pain, suggesting its potential for osteoarthritis prevention or treatment.
Does type 2 diabetes cause bone loss?
Did you know that diabetes can also affect your bone health? Individuals with Type 1 diabetes (the loss of insulin produced by the pancreas) or Type 2 diabetes (the body’s inability to use insulin and a slow loss of one’s ability to make insulin) have an increased risk of bone fractures and osteoporosis.
Is type 2 diabetes a risk factor for osteoporosis?
Having either type 1 or type 2 diabetes increases a patient’s risk of developing an osteoporosis-related fracture. BMD measurements, although supportive of the diagnosis of osteoporosis in diabetic populations, are not foolproof assessment tools.
What are the two types of osteoporosis?
Two categories of osteoporosis have been identified: primary and secondary. Primary osteoporosis is the most common form of the disease and includes postmenopausal osteoporosis (type I), and senile osteoporosis (type II). Secondary osteoporosis is characterized as having a clearly definable etiologic mechanism.