How does diabetes mellitus cause osteoporosis?

Diabetes mellitus (DM) increases osteoclast function but decreases osteoblast function, thereby leading to accelerated bone loss, osteopenia and osteoporosis.

Why does diabetes cause osteoporosis?

People with diabetes tend to have low vitamin D levels. Vitamin D is an important nutrient that helps the body absorb calcium, which is needed to maintain bone density. Elevated blood glucose levels lead to chronic inflammation which directly affects the quality and strength of the bone.

Is diabetes mellitus a risk factor for osteoporosis?

Diabetes is also an increasingly prevalent disease, with significant associated morbidity and mortality. Additionally, it has become apparent in recent years that both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are associated with an increased risk of osteoporosis-associated fractures [1–3].

How does insulin deficiency cause osteoporosis?

Higher glucose levels in the blood are known to interact with several proteins to form advanced glycation end (AGE) products. Yamagishi et al hypothesized that AGE-products in collagen may interact with bone to reduce bone strength, resulting in osteoporosis in patients with diabetes.

How diabetes affect bones?

If you have diabetes, you’re at increased risk of various bone and joint disorders. Certain factors, such as nerve damage (diabetic neuropathy), arterial disease and obesity, may contribute to these problems — but often the cause isn’t clear.

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What are the two types of osteoporosis?

Two categories of osteoporosis have been identified: primary and secondary. Primary osteoporosis is the most common form of the disease and includes postmenopausal osteoporosis (type I), and senile osteoporosis (type II). Secondary osteoporosis is characterized as having a clearly definable etiologic mechanism.

Do diabetics have weak bones?

Diabetes affects your blood sugar, but it can have many other consequences — including weaker bones. Poor bone health can have a direct relationship to diabetes as well as be a result of other diabetes complications. The first link to bone health and diabetes is osteoporosis, a condition that leads to thinning bones.

Does diabetes affect the kidneys?

Diabetes can harm the kidneys by causing damage to: Blood vessels inside your kidneys. The filtering units of the kidney are filled with tiny blood vessels. Over time, high sugar levels in the blood can cause these vessels to become narrow and clogged.

The diabetes–osteoporosis link

People with diabetes, particularly type 1 diabetes, often have poorer bone quality and an increased risk of fractures. Those with long-standing disease and poor blood sugar control, and who take insulin have the highest fracture risk.

Why does hyperthyroidism cause osteoporosis?

What is the link between thyroid disease and osteoporosis? Thyroid hormone affects the rate of bone replacement. Too much thyroid hormone (i.e. thyroxine) in your body speeds the rate at which bone is lost. If this happens too fast the osteoblasts may not be able to replace the bone loss quickly enough.

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What medical research indicates that there might be a relationship between diabetes and osteoporosis?

The review of 12 studies showed that people with Type 2 diabetes are 70% more likely to fracture their hip and in the review of 6 studies, those with Type 1 over 6 times more likely to do so.

Can diabetes be cured completely?

No cure for diabetes currently exists, but the disease can go into remission. When diabetes goes into remission, it means that the body does not show any signs of diabetes, although the disease is technically still present.

Can you reverse diabetes?

According to recent research, type 2 diabetes cannot be cured, but individuals can have glucose levels that return to non-diabetes range, (complete remission) or pre-diabetes glucose level (partial remission) The primary means by which people with type 2 diabetes achieve remission is by losing significant amounts of …

What is diabetic hand syndrome?

The tropical diabetic hand syndrome (TDHS) is a complication affecting patients with diabetes mellitus in the tropics. The syndrome encompasses a localized cellulitis with variable swelling and ulceration of the hands, to progressive, fulminant hand sepsis, and gangrene affecting the entire limb.

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