Background: Osteoporosis is an age-associated disease, which is influenced by genetic, epigenetic and environmental factors.
Is osteoporosis genetically inherited?
Osteoporosis is a polygenic disorder, determined by the effects of several genes, each with relatively modest effects on bone mass and other determinants of fracture risk. It is only on rare occasions that osteoporosis occurs as the result of mutations in a single gene.
Is osteoporosis an age related disease?
Osteoporosis, a classical age-related disease and known to be more common in women than in men, has been reported increasingly often in men during the past few years.
What percentage of osteoporosis is genetic?
Studies on osteoporosis sibs and families demonstrated that genetic factors are responsible for about 60–85% of inter-individual variability of bone mineral density (BMD) [1, 2], and this effect appears to persist even in the late decades of life. BMD heritability varies between different skeletal sites .
Does osteoporosis affect eyes?
Osteoporosis is associated with increased risk of developing dry eye syndrome, which can cause blurred vision and increase the risk of fall and fracture.
What organs are affected by osteoporosis?
Osteoporotic bone breaks are most likely to occur in the hip, spine or wrist, but other bones can break too. In addition to causing permanent pain, osteoporosis causes some patients to lose height. When osteoporosis affects vertebrae, or the bones of the spine, it often leads to a stooped or hunched posture.
What happens if osteoporosis is left untreated?
What can happen if osteoporosis is not treated? Osteoporosis that is not treated can lead to serious bone breaks (fractures), especially in the hip and spine. One in three women is likely to have a fracture caused by osteoporosis in her lifetime. Hip fractures can cause serious pain and disability and require surgery.
Should I worry if I have osteoporosis?
Talk with your doctor about an earlier scan if you have any warning signs or risk factors for osteoporosis: a bone fracture after age 50. sudden back pain. loss of height or increasingly stooped posture.
What age do you usually get osteoporosis?
At some point, usually around age 35, women start to lose bone. While some bone is lost each year, the rate of bone loss increases dramatically in the 5 to 10 years after menopause. Then, for several years, the breakdown of bone occurs at a much greater pace than the building of new bone.
What are the two medications that may cause osteoporosis after long term use?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
What are the three stages of osteoporosis?
The stages of Osteoporosis
- Osteoblasts vs Osteoclasts. Active Osteoblasts. …
- Peak bone density and the first stages of osteopenia and osteoporosis. …
- The second stage of osteopenia and osteoporosis. …
- The third stage of osteopenia and osteoporosis. …
- The fourth stage of osteopenia and osteoporosis.
What foods are bad for osteoporosis?
7 Foods to Avoid When You Have Osteoporosis
- Salt. …
- Caffeine. …
- Soda. …
- Red Meat. …
- Alcohol. …
- Wheat Bran. …
- Liver and Fish Liver Oil.