Why does glucocorticoid cause osteoporosis?

Glucocorticoids decrease the function of the remaining osteoblasts directly and indirectly through the inhibition of insulin-like growth factor I expression. The stimulation of bone resorption is likely responsible for the initial bone loss after glucocorticoid exposure.

Do glucocorticoids increase osteoporosis?

Glucocorticoid therapy is associated with an appreciable risk of bone loss, which is most pronounced in the first few months of use. In addition, glucocorticoids increase fracture risk, and fractures occur at higher bone mineral density (BMD) values than occur in postmenopausal osteoporosis.

Why osteoporosis occurs in glucocorticoid excess?

Fractures tend to occur at higher BMD levels than in women with postmenopausal osteoporosis. Glucocorticoids have direct and indirect effects on the skeleton. They impair the replication, differentiation, and function of osteoblasts and induce the apoptosis of mature osteoblasts and osteocytes.

How do corticosteroids lead to osteoporosis?

Causes and Risk Factors

Corticosteroids tend to both reduce the body’s ability to absorb calcium and increase how fast bone is broken down. The more of these drugs you take and the longer you take them, the greater your risk of developing osteoporosis.

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How do glucocorticoids affect bones?

Glucocorticoids cause profound effects on bone cell replication, differentiation, and function. Glucocorticoids increase bone resorption by stimulating osteoclastogenesis by increasing the expression of RANK ligand and decreasing the expression of its decoy receptor, osteoprotegerin.

How do glucocorticoids induce osteoporosis?

Glucocorticoids decrease the function of the remaining osteoblasts directly and indirectly through the inhibition of insulin-like growth factor I expression. The stimulation of bone resorption is likely responsible for the initial bone loss after glucocorticoid exposure.

How do you prevent bone loss when taking prednisone?

To protect your bones, do weight-bearing exercise, avoid alcohol and don’t smoke. Taking calcium and vitamin D supplements is another step you can take to help reduce the amount of bone loss caused by corticosteroids such as prednisone.

How does Cushing syndrome causes osteoporosis?

In the patients with Cushing’s syndrome, excess endogenous glucocorticoids increase bone resorption and decrease bone formation and also act to depress intestinal calcium absorption and increase urinary calcium excretion, leading to compensatory stimulation of parathyroid hormone secretion.

How does hyperthyroidism cause osteoporosis?

If you have hyperthyroidism—that is, your body produces too much T4—you have an increased risk of developing osteoporosis because being hyperthyroid can trigger an imbalance of bone-eroding activity by the osteoclasts.

What are the worst side effects of prednisone?

What are the serious side effects of prednisone?

  • Hiccups.
  • Puffiness of the face (moon face)
  • Growth of facial hair.
  • Thinning and easy bruising of the skin.
  • Impaired wound healing.
  • Glaucoma.
  • Cataracts.
  • Ulcers in the stomach and duodenum.

Can steroid induced osteoporosis be reversed?

The accompanying biochemical changes, particularly the marked increase in serum osteocalcin levels, confirm that enhanced bone formation occurred during the recovery phase. These findings suggest that steroid-induced osteoporosis can be reversed at least in young persons.

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How is steroid induced osteoporosis treated?

The first-line drugs for treatment of glucocorticoid-induced osteoporosis include bisphosphonates: alendronate and risedronate, while zoledronate or teriparatide should be considered as the second option. The effectiveness of other therapeutic agents has not been proven yet.

How long does it take for prednisone to cause osteoporosis?

How quickly can bone loss occur when taking a steroids? Bone loss occurs most rapidly in the first 6 months after starting oral steroids.

Why do glucocorticoids increase blood sugar?

One of their side effects is to increase blood glucose (sugar) since these drugs promote glucose production in the liver and reduce the sensitivity of the cells to insulin. Consequently, glucose accumulates in the blood and can cause a rise in blood sugar levels.

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